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    宋智勇
    發布時間:2017-10-25

      

    宋智勇,男,副教授,理學博士,近年來主要圍繞智能化納米材料的設計與可控制備,用于藥物的定點、可控釋放,以耐藥性細菌為研究對象,開展納米化學生物學效應研究。目前以第一作者或通訊作者在Nature Communications,Advanced Functional Materials, Small,Biomaterials,Chemical engineering journal,ACSAppliedMaterials &Interfaces,Environmental Science: Nano,Chemical Communications等國際學術期刊上發表論文13篇,其中影響因子大于10的論文5篇,大于5的論文9篇。目前主持國家自然科學,華中農業大學校自主創新基金等多項基金。

    研究領域

    (1)納米材料的設計與可控制備,用于藥物分子的定點、可控釋放;

    (2)無抗生素納米載藥系統的構建及其針對超級細菌感染治療;

    科研項目

    (1)國家自然科學基金委員會,青年項目,21807036,跨血腦屏障CRISPR/Cas13a遞送系統的構建及其對狂犬病的治療研究,2019年01月至2021年12月,27.5萬,在研;

    (2)華中農業大學自主創新基金,培育專項,2662020LXPY007,細胞膜仿生納米平臺構建及其用于幽門螺旋桿菌靶向治療研究,2020年05月至2023年4月,21萬,在研;

    (3)華中農業大學,教師啟動基金,納米材料介導的單克隆抗體細胞內遞送及協同抗病毒治療,2016年09月至2019年8月,15萬,結題。

    近5年代表性論文

    (1)YangWu#,ZhiyongSong#, HuajuanWang, HeyouHan* Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infectionsNature communications, 2019, 10 (1), 1-10.

    (2)ZhiyongSong#, YangWu#, QiCao, HuajuanWang, XiangruWang, HeyouHan*.pH‐Responsive, Light‐Triggered on‐Demand Antibiotic Release from Functional Metal–Organic Framework for Bacterial Infection Combination Therapy,Advanced Functional Materials, 2018, 28 (23), 1800011.

    (3)YangWu, GuiyunDeng, KaiJiang, HuajuanWang,ZhiyongSong*, HeyouHan*. Photothermally triggered nitric oxide nanogenerator targeting type IV pili for precise therapy of bacterial infections,Biomaterials, 2020, 120588.

    (4)HuajuanWang#, JinZhang#,ZhiyongSong#, YongliMu, MF Foda, YangWu, HeyouHan.An intelligent platform based on acidity-triggered aggregation of gold nanoparticles for precise photothermal ablation of focal bacterial infection,Chemical Engineering Journal, 2020, 127076.

    (5)ZhiyongSong, XiaoyuWang*, GenxinZhu, QinggongNian, HangyuZhou, DongYang, ChenfengQin, RuikangTang*.Virus Capture and Destruction by Label‐Free Graphene Oxide for Detection and Disinfection Applications,Small, 2015, 11 (9-10), 1171-1176.

    (6)ShuojunLi#,ZhiyongSong#, CaiyunLiu, XiaolinChen*, HeyouHan*.Biomimetic Mineralization-Based CRISPR/Cas9 Ribonucleoprotein Nanoparticles for Gene Editing,ACS Applied Materials & Interfaces, 2019, 11 (51), 47762-47770

    (7)JunMa#,ZhiyongSong#, JianhongYang, YouningWang, HeyouHan*.Cobalt Ferrite Nanozyme for Efficient Symbiotic Nitrogen Fixation via Regulating Reactive Oxygen Metabolism,Environmental Science: Nano, 2020.

    (8)ZhiyongSong#, YangWu#, HuajuanWang, HeyouHan*. Synergistic antibacterial effects of curcumin modified silver nanoparticles through ROS-mediated pathways,Materials Science and Engineering: C, 2019, 99, 255-263.

    (9)ZhiyongSong, LongLiu, XiaoyuWang, YongqiangDeng, QingongNian, GuanchuanWang, ShunyaZhu, XiaofengLi, HangyuZhou, TaoJiang, XurongXu, RuikangTang*, ChenfengQin*. Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection,Chemical Communications, 2016, 52(9): 1879-1882.

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